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Introduction Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), was declared a pandemic by the World Health Organization on 11th March 2020 and has become a major global health concern

Several papers explored: dopaminergic signaling serotonergic interactions nitric oxide pathway modulation neuroprotective activity gut-brain axis relationships These discussions led to more interest in whether gastrointestinal stabilization might indirectly influence mood regulation, stress tolerance, cognitive clarity, reward signaling, and emotional stability

Src-Caveolin-1-eNOS Pathway This pathway produces nitric oxide for vasodilation, improving blood flow to injured areas

Researchers have used this combination to explore how parallel modulation of amylin and GLP-1 receptors may influence metabolic outcomes

This dual action promotes the remodeling of scar tissue into normal tissue, rather than merely increasing collagen production

Cell 43(2):405413